Introduction.-The larynx is a rare site of deposition for amyloidosis. Diag
nosis may be delayed and evoked in patients with prolonged hoarseness. We h
ave reported two cases of laryngeal amyloidosis.
Exegesis.-One man and one woman suffered from hoarseness during one and thr
ee years, respectively. Laryngoscopic examination showed diffuse infiltrati
on of the larynx. Amyloidosis was confirmed by the characteristic Congo-red
staining of laryngeal biopsies. The search for other localizations of amyl
oidosis was negative. No monoclonal plasma cell proliferation was detected.
Both patients received endoscopic CO, laser excision, In one case, chemoth
erapy was initially associated due to dystrophic plasma cells in bone marro
w aspiration and then withdrawn because of clinical failure. With a 6-month
follow-up, hoarseness remained stable.
Conclusion.-Laryngeal amyloidosis is an essentially localized disease revea
led by hoarseness. Treatment is endoscopic by laser excision. In nearly hal
f of the cases in the literature, it had to be repeated due to localized re
current lesions. Long-term prognosis of localized laryngeal amyloidosis is
better than systemic AL amyloidosis. (C) 2000 Editions scientifiques et med
icales Elsevier SAS.