alpha-aminoazoles in the synthesis of heterocycles: I. Synthesis of regioisomeric 5-methyl-2,7-diphenyl- and 7-methyl-2,5-diphenylpyrazolo[1,5-a]pyrimidines

Authors
Petrov, AA Emelina, EE Firsov, AV
Citation
Aa. Petrov et al., alpha-aminoazoles in the synthesis of heterocycles: I. Synthesis of regioisomeric 5-methyl-2,7-diphenyl- and 7-methyl-2,5-diphenylpyrazolo[1,5-a]pyrimidines, RUSS J ORG, 36(7), 2000, pp. 1027-1032
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
10704280 → ACNP
Volume
36
Issue
7
Year of publication
2000
Pages
1027 - 1032
Database
ISI
SICI code
1070-4280(200007)36:7<1027:AITSOH>2.0.ZU;2-V
Abstract
4-Phenyl-3-butyn-2-one reacts with 3(5)-amino-5(3)-phenylpyrazole on heatin g in DMSO to give 7-methyl-2,5-diphenylpyrazolo[1,5-a]pyrimidine. The react ion of 3(5)-amino-5(3)-phenylpyrazole with benzoylacetone in chloroform, et hanol, and DMSO results in formation of a mixture of isomeric pyrazolopyrim idines, the major product being 5-methyl-2,7-diphenylpyrazolo[1,5-a]pyrimid ine.