Immunosuppression in liver transplantation

Prevention of graft rejection while minimizing morbidity remains the single most important objective in liver transplantation. Advances in immunosuppr ession have provided excellent patient and graft survival with relatively l ow incidences of acute rejection. However it is apparent that the toxicity of the present immunosuppressive drugs accounts for much of the morbidity a fter transplantation. Attention is now being focused on combination drug th erapies to reduce morbidity while maintaining the excellent results achieve d with present immunosuppressive agents.