An improved procedure for the mild racemization of N-acyl alpha-amino acids

Authors
Hateley, MJ Schichl, DA Fischer, C Beller, M
Citation
Mj. Hateley et al., An improved procedure for the mild racemization of N-acyl alpha-amino acids, SYNLETT, (1), 2001, pp. 25-28
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
1
Year of publication
2001
Pages
25 - 28
Database
ISI
SICI code
0936-5214(200101):1<25:AIPFTM>2.0.ZU;2-N
Abstract
An improved procedure for the mild racemization of N-acyl alpha -amino acid s has been developed, using Pd(PPh3)(4) either as the pre-formed complex or by its in situ formation from Pd(OAc)(2) or Pd-2(dba)(3) and triphenylphos phine. The concentration of the palladium complex catalyst required for eff ective racemization is much lower than for the previously reported rhodium based catalytic system. In addition, the racemization also proceeds more ra pidly at this lower catalyst concentration.