Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds

Authors
Lelievre, D Bure, C Laot, F Delmas, A
Citation
D. Lelievre et al., Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds, TETRAHEDR L, 42(2), 2001, pp. 235-238
Citations number
18
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
2
Year of publication
2001
Pages
235 - 238
Database
ISI
SICI code
0040-4039(20010108)42:2<235:SOPDPF>2.0.ZU;2-T
Abstract
To synthezise a triple-function branched peptide in a modular way, we prese nt a new strategy based on orthogonal generation of two aldehyde functions from an acetal and a 2-amino alcohol. Successive unmaskings of aldehyde fun ctions of the stem peptide affords stepwise chemoselective ligations of two (aminooxy)acetyl peptides via oxime bonds. (C) 2000 Elsevier Science Ltd. All rights reserved.