Synthesis of a heterocyclic receptor for carboxylic acids

Authors
Moore, G Levacher, V Bourguignon, J Dupas, G
Citation
G. Moore et al., Synthesis of a heterocyclic receptor for carboxylic acids, TETRAHEDR L, 42(2), 2001, pp. 261-263
Citations number
23
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
2
Year of publication
2001
Pages
261 - 263
Database
ISI
SICI code
0040-4039(20010108)42:2<261:SOAHRF>2.0.ZU;2-P
Abstract
The synthesis of a tricyclic receptor having a bowl shape and three binding points for carboxylic acids has been achieved starting from readily availa ble 1-tetralone derivatives. This host possesses a six-membered lactam moie ty and a carboxamide at the end of a flexible arm. The association constant with benzoic acid and the stoichiometry of the complex have been determine d using H-1 NMR dilution experiments. (C) 2000 Elsevier Science Ltd. All ri ghts reserved.