Synthesis of cyclic peptides as mimics for the constrained conformation ofstructural analogues of HIV protease inhibitors

Authors
Prabhakaran, EN Rajesh, V Dubey, S Iqbal, J
Citation
En. Prabhakaran et al., Synthesis of cyclic peptides as mimics for the constrained conformation ofstructural analogues of HIV protease inhibitors, TETRAHEDR L, 42(2), 2001, pp. 339-342
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
2
Year of publication
2001
Pages
339 - 342
Database
ISI
SICI code
0040-4039(20010108)42:2<339:SOCPAM>2.0.ZU;2-W
Abstract
A gamma -turn induced cyclisation of tripeptides 4 can be performed in a ri ng-closing metathesis reaction using Grubb's catalyst to the corresponding cyclic peptides 5. These cyclic peptides mimic the constrained conformation of structural analogues of potential HIV protease inhibitors. (C) 2000 Els evier Science Ltd. All rights reserved.