V. Polo et al., Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in open-angle glaucoma, ACT OPHTH S, 79(1), 2001, pp. 6-9
Purpose: To compare the effect on intraocular pressure of latanoprost versu
s timolol plus dorzolamide in open-angle glaucoma.
Methods: Thirty-five patients with open-angle glaucoma were randomized, 18
to latanoprost once daily and 17 to timolol plus dorzolamide twice daily. I
ntraocular pressure and ocular side effects were recorded at baseline, and
after 2 weeks and 3 months of treatment.
Results: Latanoprost reduced the intraocular pressure 1.09 and 1.58 mm Hg m
ore than timolol plus dorzolamide after 2 weeks and 3 months of treatment,
respectively. These differences were statistically significant (p<0.05) at
the end of the study. After 3 months of treatment, 32.3% of the eyes in the
latanoprost group reduced the intraocular pressure in 30% or more with res
pect to baseline, while 15.6% of the eyes in the timolol plus dorzolamide g
roup achieved this reduction.
Conclusions: Latanoprost administered once daily reduced the intraocular pr
essure at least as well as timolol plus dorzolamide twice daily in patients
with open-angle glaucoma.