The inhibition of protein adsorption to the surfaces of biomedical devices
is a crucial requirement for avoiding implant-associated infections or thro
mbus formation on blood-contacting artificial surfaces and thus for increas
ing the long-term biocompatibility of the devices. Here, the use of surface
plasmon resonance and scanning force microscopy using protein-modified tip
s (see Figure) to study protein adhesion on poly (ethylene glycol) grafted
polymer materials is discussed. The PEG-grafted materials are revealed to h
ave significantly reduced affinity to proteins.