Effect of 6 dietary fatty acids on the postprandial lipid profile, plasma fatty acids, lipoprotein lipase, and cholesterol ester transfer activities in healthy young men

Background: There is increasing evidence that postprandial triacylglycerol- rich lipoproteins may be related to atherogenic risk. Objective: The objective was to investigate the effect of individual fatty acid intakes on postprandial plasma lipoprotein triacylglycerol and cholest erol concentrations, plasma fatty acids, and preheparin lipoprotein lipase and cholesterol ester transfer protein (CETP) activities. Design: Six test fats high (approximate to 43% by wt) in stearic acid, palm itic acid, palmitic + myristic acid, oleic acid, elaidic acid (trans 18:1), and linoleic acid were produced by interesterification. After having faste d for 12 h, 16 healthy young men were served the individual test fats incor porated into meals (1 g fat/kg body wt) in random order on different days s eparated by washout periods. Blood samples were drawn before and 2, 4, 6, a nd 8 h after the meals. Results: Different responses to the test-fat meals were observed for plasma lipoprotein triacylglycerol and cholesterol concentrations, plasma fatty a cid concentrations, and lipoprotein lipase and CETP activities (diet x time interaction: 0.001 < P < 0.05). Intake of the long-chain saturated fatty a cids stearic and palmitic acids resulted in a relatively lower lipemic resp onse than did intake of the unsaturated fatty acids, probably because the s aturated fatty acids were absorbed less and at a lower rate; therefore, the lipemic response took longer to return to postabsorptive values. Conclusions: Fatty acid chain length and degree of saturation appear to aff ect the extent and duration of lipemia and affect hepatic output indirectly . These effects may not be mediated via effects on lipoprotein lipase and C ETP activities.