Random genetic drift determines the level of mutant mtDNA in human primaryoocytes

Authors
Brown, DT Samuels, DC Michael, EM Turnbull, DM Chinnery, PF
Citation
Dt. Brown et al., Random genetic drift determines the level of mutant mtDNA in human primaryoocytes, AM J HU GEN, 68(2), 2001, pp. 533-536
Citations number
24
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Molecular Biology & Genetics
Journal title
AMERICAN JOURNAL OF HUMAN GENETICS
ISSN journal
00029297 → ACNP
Volume
68
Issue
2
Year of publication
2001
Pages
533 - 536
Database
ISI
SICI code
0002-9297(200102)68:2<533:RGDDTL>2.0.ZU;2-H
Abstract
We measured the proportion of mutant mtDNA (mutation load) in 82 primary oo cytes from a woman who harbored the A3243G mtDNA mutation. The frequency di stribution of mutation load indicates that random drift is the principal me chanism that determines the level of mutant mtDNA within individual oocytes .