The multiple oppositions approach (Williams, 1992; 2000) was incorporated a
s the beginning point of intervention for 10 children who exhibited moderat
e-to-profound phonological impairments. Several variables that potentially
affect phonological change were examined in a longitudinal case study of th
ese children. Different models of intervention (multiple oppositions, minim
al pairs, and naturalistic speech intelligibility training) were incorporat
ed within different structures of treatment (vertical, horizontal, and cycl
ical) using a model of phonologic learning that was based on a developmenta
l structuring of intervention. This nontraditional research paradigm is pro
posed as a possible bridge to link the science and practice of clinical res
earch. Specifically, the clinical reality of providing intervention to chil
dren from their initial treatment to discharge provides a broader perspecti
ve of treatment efficacy while also serving as a foundation for future area
s of more controlled investigations of specific variables.