Wegener's disease and central diabetes insipidus

Vasculitis with central diabetes insipidus is a rare condition which must b e recognized for proper management. We report a case of Wegener's granulomatosis with diabetes insipidus and re view the literature concerning the clinical and radiological features of th is association. We examined the data supporting the efficacy of cyclophosph amide in diabetes insipidus. Diabetes insipidus is inaugural in 46 % of cas es. Wegener's granulomatosis has no distinctive features when associated wi th diabetes insipidus. MR imaging reveals an enlargement of the posterior p ituitary in 100 % of cases. Cyclophosphamide is effective in 80 % of cases. In Wegener's granulomatosis, pituitary vasculitis is a rare condition. MR i maging is the most accurate method for pituitary exploration. Cyclophospham ide is effective in the treatment of vasculitis lesions in Wegener's granul omatosis.