Anisotropic mechanisms for multiphasic unipolar electrograms: Simulation studies and experimental recordings

The origin of the multiple, complex morphologies observed in unipolar epica rdial electrograms, and their relationships with myocardial architecture, h ave not been their elucidated. To clarify this problem we simulated electro grams (EGs) with a model representing the heart as an anisotropic bidomain with unequal anisotropy ratio, ellipsoidal ventricular geometry, transmural fiber rotation, epi-endocardial obliqueness of fiber direction and a simpl ified Purkinje network. The EGs were compared with those directly recorded from isolated dog hearts immersed in a conducting medium during ventricular excitation initiated by epicardial stimulation. The simulated EGs share th e same multiphasic character of the recorded EGs. The origin of the multipl e waves, Especially those appearing in the EGs for sites reached by excitat ion wave fronts spreading across fibers, can be better understood after spl itting the current sources, the potential distributions and the EGs into an axial and a conormal component and after taking also into account the effe ct of the reference or drift component. The split model provides an explana tion of humps and spikes that appear in the QRS (the initial part of the ve ntricular EG) wave forms, in terms of the interaction between the geometry and direction of propagation of the wave front and the architecture of the fibers through which excitation is spreading. (C) 2000 Biomedical Engineeri ng Society. [S0090-6964(00)00511-7].