Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis

Authors
Sharma, S Verma, I Khuller, GK
Citation
S. Sharma et al., Therapeutic potential of human neutrophil peptide 1 against experimental tuberculosis, ANTIM AG CH, 45(2), 2001, pp. 639-640
Citations number
10
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
2
Year of publication
2001
Pages
639 - 640
Database
ISI
SICI code
0066-4804(200102)45:2<639:TPOHNP>2.0.ZU;2-J
Abstract
The therapeutic efficacy of human neutrophil peptide 1 (HNP-1) against expe rimental tuberculosis in mice on the basis of numbers of CFU has been exami ned. Mice infected with 1.5 x 10(4) CFU of Mycobacterium tuberculosis H(37) Rv and treated with different doses of HNP-1 injected subcutaneously exhibi ted significant clearance of bacilli from lungs, livers, and spleens. There were time- and dose-dependent decreases in the bacillary load in lungs, li vers, and spleens of the HNP-1-treated animals compared to that in controls (untreated animals). These observations strongly suggest the therapeutic a ctivity of HNP-1 against tuberculosis.