G. Garcia-calvo et al., Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers, ANTIM AG CH, 45(2), 2001, pp. 608-611
Gemifloxacin and trovafloxacin were administered to 12 volunteers in a rand
omized crossover trial with a 2-week washout period. Stool samples were col
lected predose and 1, 2, and 3 days postdose. Both quinolones reduced the n
umber of organisms of the family Enterobacteriaceae and aerobic gram-positi
ve organisms. Escherichia coli reduction was greater with gemifloxacin than
with trovafloxacin, with postdose isolation of quinolone-resistant strains
for which MICs of trovafloxacin were higher than those of gemifloxacin.