Comparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin B colloidal dispersion) and conventional deoxycholate formulations of amphotericin B in rabbits

Authors
Clemons, KV Sobel, RA Williams, PL Stevens, DA
Citation
Kv. Clemons et al., Comparative toxicities and pharmacokinetics of intrathecal lipid (amphotericin B colloidal dispersion) and conventional deoxycholate formulations of amphotericin B in rabbits, ANTIM AG CH, 45(2), 2001, pp. 612-615
Citations number
19
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
45
Issue
2
Year of publication
2001
Pages
612 - 615
Database
ISI
SICI code
0066-4804(200102)45:2<612:CTAPOI>2.0.ZU;2-A
Abstract
The lipid formulation of amphotericin B, Amphotec (ABCD), has not been used intrathecally. After a single intrathecal dose or after four doses, conven tionally formulated deoxycholate amphotericin B (AMB) (Fungizone) resulted in higher levels of amphotericin B in the cerebrospinal fluid of rabbits th an did ABCD. Clinically and histologically, ABCD was about threefold less t oxic than AMB after a single dose and 3- to 30-fold less toxic after multip le dosing. These data are encouraging for the potential use of ABCD as an i ntrathecal treatment.