Synthesis and antinociceptive activity of (2-benzazolon-3-yl)propionamide derivatives

The syntheses of (2-benzothiazolinon-3-yl)propionamide and (2-benzoxazolino n-3-yl)propionamide derivatives are reported. The structures of these compo unds are elucidated by their IR and H-1-NMR spectral data, as well as by el emental analysis. The compounds were tested for antinociceptive activity by hot plate, tail flick, tail clip, and modified Koster tests. Compounds 6b and 7d were found to be the most promising compounds among the substances i nvestigated.