Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes

Authors
Steck, E Benz, K Lorenz, H Loew, M Gress, T Richter, W
Citation
E. Steck et al., Chondrocyte expressed protein-68 (CEP-68), a novel human marker gene for cultured chondrocytes, BIOCHEM J, 353, 2001, pp. 169-174
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL JOURNAL
ISSN journal
02646021 → ACNP
Volume
353
Year of publication
2001
Part
2
Pages
169 - 174
Database
ISI
SICI code
0264-6021(20010115)353:<169:CEP(AN>2.0.ZU;2-6
Abstract
In the search for new marker genes suitable to distinguish chondrocytes fro m osteoblasts and mesenchymal stem cells in culture, we have identified and characterized a novel gene called chondrocyte expressed protein-68 (CEP-68 ), harbouring an N-terminal leader peptide and an epidermal growth factor-l ike calcium-binding domain. CEP-68 defines a new family of proteins and com plements collagen type II as a new marker for stem-cell-based chondrogenic tissue engineering.