Effect of liv.100, an ayurvedic formulation on the erythrocyte antioxidantstatus in antitubercular drug-induced liver injury in rats

The protective effect of Liv. 100, an ayurvedic formulation on the antioxid ant status of erythrocytes in antitubercular drug [Isoniazid (INH), Rifampi cin (RMP) and Pyrazinamide (PZA)]-induced hepatotoxicity in rats was studie d. Administration of antitubercular (anti-TB) drugs for 6 weeks resulted in a significant decrease in the activities of erythrocyte antioxidant enzyme s with a concomitant increase in serum and erythrocyte lipid peroxides leve l. The levels of serum antioxidants such as vitamin-E, ascorbate and blood glutathione decreased on anti-TB drug treatment. Simultaneous treatment wit h Liv. 100 reduced the inactivation of erythrocyte antioxidant enzymes and formation of lipid peroxides. The antioxidant levels were also maintained a t near normal in Liv. 100 co-administered rats. Liv. 100 by its antioxidant potential reduces free radical-mediated erythrocyte oxidative damage.