Cryofibrinogenemia acid skin necrosis in a patient with diffuse large celllymphoma after high-dose chemotherapy and autologous stem cell transplantation

A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma pre sented 60 days after high-dose chemotherapy and autologous stem cell transp lantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis lu the ears and extremities. Extensive work-up revealed the presen ce of cryofibrinogenemia and associated thrombotic vasculopathy, The patien t was successfully treated with corticosteroids and therapeutic plasma exch ange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may ha ve occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2.