Nonrandom chromosome changes in Kaposi sarcoma: cytogenetic and FISH results in a new cell line (KS-IMM) and literature review

The karyotype of a new tumorigenic Kaposi sarcoma (KS)-derived cell line, a s defined by cytogenetic and fluorescence in situ hybridization (FISH) anal ysis is 49,XY,i(1)(q10),i(7)(F10),+i(7) (q10).+der(8)t(8;13)(p11;s11).-13,del(15)(q22),+der(17)t(1;17)(p13;p13). Our aim was to point out some charac teristics and recurrent chromosome changes probably playing a relevant role in the malignant progression of KS, by a comparison of the cytogenetic res ults obtained in the present study with data from the literature. The inter pretation of the cytogenetic results is that KS development occurs by multi ple steps: an initial reactive polyclonal cell proliferation is associated with chromosome instability; the cells in a later stage acquire clonal chro mosome changes. If many chromosome changes are present, particularly Sq and Iq trisomy. 3p14-->pter deletion, 1p13, 13p14.3, 7q22, 8p11, 13q11, and 19 q13 band rearrangements, KS acquires a neoplastic aggressive state. (C) 200 1 Elsevier Science Inc. All rights reserved.