Chromosomal abnormalities in pituitary adenomas

Cytogenetic studies were conducted on 30 pituitary adenomas, using both dir ect and/or short-term in vitro culture methods. An apparently normal chromo some complement was found in 14 tumors: 5 adenomas were characterized by hy perdiploid or near-triploid modal chromosome numbers. Re current numerical deviations were identified in 12 samples, which primarily involved gains of chromosomes 4, 7, 8. 91 12, and 20 by gains, and losses of chromosomes 10, 14, 19, and 22. Four adenomas were shown to have structural chromosome rea rrangements with no apparent recurrent pattern of involvement. (C) Elsevier science Inc., 2001. All rights reserved.