Acute effects of transdermal estrogen in postmenopausal women with coronary artery disease - Using a clinically relevant estrogen dose and concurrentantianginal therapy

In the present study the acute anti-ischemic effect of clinically relevant doses of transdermal estradiol during concurrent antianginal therapy was in vestigated in 14 postmenopausal women with stable coronary artery disease, Plasma estradiol was significantly increased, but no significant effects on time to angina, time to 1 mm S-T depression, total exercise time, maximum rate-pressure product, maximum S-T depression or maximum workload were foun d, However, resting diastolic blood pressure was significantly decreased du e to estrogen, Copyright (C) 2001 S. Karger AG, Basel .