Synthesis of distamycin analogs and their interactions with calf thymus DNA

Citation
Jh. Xiao et al., Synthesis of distamycin analogs and their interactions with calf thymus DNA, CHIN J CHEM, 19(1), 2001, pp. 116-118
Citations number
17
Categorie Soggetti
Chemistry
Journal title
CHINESE JOURNAL OF CHEMISTRY
ISSN journal
1001604X → ACNP
Volume
19
Issue
1
Year of publication
2001
Pages
116 - 118
Database
ISI
SICI code
1001-604X(200101)19:1<116:SODAAT>2.0.ZU;2-N
Abstract
Two distamycin analogs (PyPyPy-gamma -Dp and PyPyPyPy-gamma -Dp) were synth esized by a haloform reaction and the DCC/HOBT coupling reaction in a simpl e and fast way without amino protection. Ey using calf thymus DNA, the inte raction between the analogs and DNA duplex was studied by CD, and ITC.