Acute leukemia diagnosis aid using multicriteria fuzzy assignment methodology

We recently developed ii new multicriteria classification method called PRO AFTN to help medical diagnosis. The aim of this paper is to present the app lication of the proposed method for the diagnosis of acute leukemia (AL). T he implementation of PROAFTN was carried out on cytological data of 108 cas es of AL, using the classification rules of French, American and British he matologists, acid was then applied on an independent test set of 83 cases o f AL. Forty-seven features, obtained by examining patients' bone-marrow sme ars with light microscope, defined each case. In order to determine the per centage of correct classifications for each subtype of AL, we compared our results with the clinical diagnosis given previously by the hematologist. 9 6.4% of the cases were correctly classified by the program, suggesting that the method yields good results in terms of discrimination between AL subty pes. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.