Presentation of self and microbial lipids by CD1 molecules

Authors
Matsuda, JL Kronenberg, M
Citation
Jl. Matsuda et M. Kronenberg, Presentation of self and microbial lipids by CD1 molecules, CURR OP IM, 13(1), 2001, pp. 19-25
Citations number
55
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
13
Issue
1
Year of publication
2001
Pages
19 - 25
Database
ISI
SICI code
0952-7915(200102)13:1<19:POSAML>2.0.ZU;2-9
Abstract
CD1 molecules present both self lipids and microbial lipids. Recent studies have elucidated novel antigenic structures that can be presented by CD1 fo r T cell stimulation, as well as new pathways for lipid-antigen presentatio n. Additionally, the development of lipid-CD1 tetramers now permits the tra cking of CD1-reactive T cells during immune responses. Despite this, the ro les of CD1-reactive T cells in both host defense and immune regulation rema in to be unequivocally defined.