The control and facilitation of MHC class II antigen processing by the BCR

Antigens capable of cross-linking the BCR are preferentially captured, proc essed and presented to MHC-class-II-restricted T cells. Cross-linking antig ens initiate tyrosine-kinase-dependent pathways that accelerate the deliver y of antigen-receptor complexes to specialized late-endocytic processing co mpartments. Accelerated trafficking is mediated by the recruitment of signa ling molecules required for transience through specific checkpoints along t he endocytic pathway.