Studies of receptors and signal-transduction components that play a role in
plant disease resistance have revealed remarkable similarities with innate
immunity pathways in insects and mammals. In plants, specific receptors en
coded by disease-resistance genes interact with products of microbial effec
tor genes to activate defence responses. Resistance proteins have been foun
d to have motifs in common with components of immune response pathways in m
ammals and invertebrates, and to rely on similar downstream signalling comp
onents. In the future, the sharing of ideas among plant and animal biologis
ts is likely to broaden our understanding of defence responses in diverse o
rganisms.