CD1 and lipid antigens: intracellular pathways for antigen presentation

Authors
Jayawardena-Wolf, J Bendelac, A
Citation
J. Jayawardena-wolf et A. Bendelac, CD1 and lipid antigens: intracellular pathways for antigen presentation, CURR OP IM, 13(1), 2001, pp. 109-113
Citations number
39
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
13
Issue
1
Year of publication
2001
Pages
109 - 113
Database
ISI
SICI code
0952-7915(200102)13:1<109:CALAIP>2.0.ZU;2-Y
Abstract
Recently, different members of the CD1 family of MHC-like molecules have be en shown to sample different intracellular compartments to present lipid an d glycolipid antigens to T cells. Emerging models suggest that CD1 may have evolved to monitor the integrity of membrane lipids and/or to present micr obial lipid antigens to both alpha beta and gamma delta T cells.