EF-hand calcium-binding proteins

The EF-hand motif is the most common calcium-binding motif found in protein s. Several high-resolution structures containing different metal ions bound to EF-hand sites have given new insight into the modulation of their bindi ng affinities. Recently determined structures of members of several newly i dentified protein families that contain the EF-hand motif in some of their domains, as well as of their complexes with target molecules, are throwing light on the surprising variety of functions that can be served by this sim ple and ingenious structural motif.