Authors
Citation
Ek. Fan et al., AB(5) toxins: structures and inhibitor design, CURR OP STR, 10(6), 2000, pp. 680-686
Citations number
50
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN STRUCTURAL BIOLOGY
ISSN journal
0959440X
→ ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
680 - 686
Database
ISI
SICI code
0959-440X(200012)10:6<680:ATSAID>2.0.ZU;2-U
Abstract
High-resolution crystal structures of AB(5) toxins in their native form or
in complex with a variety of ligands have led to the structure-based design
and discovery of inhibitors targeting different areas of the toxins. The m
ost significant progress is the development of highly potent multivalent li
gands that block binding of the toxins to their receptors.