The variation in slope of concentration-effect relationships

Implementing the variation within populations in ecological modeling of ris k and effects of toxicants could contribute to a more sophisticated may of modeling. To give insight into the magnitude and spread in sensitivity with in test populations the variation in sensitivity of individuals expressed a s the slope of a concentration-effect curve (Sm) within more than 300 test populations from toxicity tests with 36 species and 116 substances is analy zed. The overall average variation from this study is 0.65 (Sm) and corresp onds to an EC50/EC5 ratio of 2.9. The mode of action is often suggested as an explanation for the different slopes of concentration-effect curves. For metals, indeed, significant different median slope values are observed com pared with organic substances. However, within the group of organic substan ces no distinction between the slope values of narcotic substances and subs tances with a specific mode of action could be made, Between species groups , significant differences in the amount of variation could be demonstrated. The median slopes for all toxicants within the data set of 96-h tests spec ified for fishes and mollusks are significantly steeper (median slopes of 0 .38 and 0.37, respectively) than those for algae and crustaceans (1.2 and 0 .72, respectively). Experimental factors that might explain these differenc es are discussed. The results from this study provide insight into the vari ation within a test population and can be used to estimate sensitivity para meters for risk and effect modeling, (C) 2001 Academic Press.