We present a case of primary amyloid tumor of the breast. Although iso
lated amyloidosis of other organs occurs frequently, it is extremely r
are in the breast: only seven well-documented cases have been reported
. Our case has the additional unusual feature of belonging to the amyl
oid AA type of amyloid instead of the more common amyloid AI, type. Im
munohistochemical studies are documented, The clinical and pathologic
characteristics of all of the reported cases are tabulated. These case
s suggest that primary amyloid tumor in the breast has the following c
linicopathologic features: it affects postmenopausal women between the
ages of 54 to 82 years (mean, 68 yr), involves the right breast more
often than the left (ratio, 3:1), is clinically frequently misdiagnose
d as carcinoma, and probably has a diverse pathogenesis.