The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting

Citation
Jm. Argiles et al., The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting, EUR CYTOKIN, 11(4), 2000, pp. 552-559
Citations number
76
Categorie Soggetti
Cell & Developmental Biology
Journal title
EUROPEAN CYTOKINE NETWORK
ISSN journal
11485493 → ACNP
Volume
11
Issue
4
Year of publication
2000
Pages
552 - 559
Database
ISI
SICI code
1148-5493(200012)11:4<552:TDEOTN>2.0.ZU;2-Q
Abstract
Tumour necrosis factor-alpha (TNF) is a pleiotropic cytokine that can have effects on many cell types, including skeletal muscle, the most abundant ti ssue (representing almost 45% of body weight), where many effects of this c ytokine have been described, Thus, TNF receptors have been described in mus cle tissue, and different investigations have revealed effects of the cytok ine on membrane potential, glucose uptake and metabolism, amino acid transp ort and protein turnover, However, the results found are relatively diverge nt, therefore the main aim of the present review has been to clarify and re concile some of the most contradictory studies concerning the effects of TN F on metabolism in skeletal muscle.