Jm. Argiles et al., The divergent effects of tumour necrosis factor-alpha on skeletal muscle: implications in wasting, EUR CYTOKIN, 11(4), 2000, pp. 552-559
Tumour necrosis factor-alpha (TNF) is a pleiotropic cytokine that can have
effects on many cell types, including skeletal muscle, the most abundant ti
ssue (representing almost 45% of body weight), where many effects of this c
ytokine have been described, Thus, TNF receptors have been described in mus
cle tissue, and different investigations have revealed effects of the cytok
ine on membrane potential, glucose uptake and metabolism, amino acid transp
ort and protein turnover, However, the results found are relatively diverge
nt, therefore the main aim of the present review has been to clarify and re
concile some of the most contradictory studies concerning the effects of TN
F on metabolism in skeletal muscle.