Archerine, a novel anti-histaminic bromotyrosine-derived compound from theCaribbean marine sponge Aplysina archeri

A further chemical investigation of the Caribbean marine sponge Aplysina ar cheri led to the isolation of a novel bromo compound, archerine (1). Its st ructure was established through extensive NMR spectroscopy, including H-1-C -13 HSQC,H-1-C-13 HMBC and H-1-N-15 HMBC experiments, as well as positive F AB MS/MS spectra. The capability of archerine to chelate zinc ions was inve stigated. Archerine exhibited antihistamine activity on the isolated guinea pig ileum at concentrations as low as 1 muM.