H. Manev et al., Antidepressants alter cell proliferation in the adult brain in vivo and inneural cultures in vitro, EUR J PHARM, 411(1-2), 2001, pp. 67-70
The action of antidepressants on cell proliferation (bromodeoxyuridine (Brd
U) or [H-3]thymidine incorporation} was studied in the adult rat hippocampu
s in vivo and in neural precursors (immature rat cerebellar granule cells)
in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitone
al treatment with fluoxetine (5 mg/kg) resulted in a 3.4-fold increase of b
romodeoxyuridine-positive cells in the subgranular zone of the dentate gyru
s. In cell cultures, at 1 and 10 days in vitro, 48-h fluoxetine exposure (1
muM. which is comparable to therapeutic plasma concentrations) reduced thy
midine incorporation when initiated at 1 day in vitro, but increased cell p
roliferation when initiated at 10 days in vitro. Clomipramine and imipramin
e produced similar action in vitro; desipramine was ineffective. (C) 2001 E
lsevier Science B.V. All rights reserved.