Antidepressants alter cell proliferation in the adult brain in vivo and inneural cultures in vitro

Citation
H. Manev et al., Antidepressants alter cell proliferation in the adult brain in vivo and inneural cultures in vitro, EUR J PHARM, 411(1-2), 2001, pp. 67-70
Citations number
14
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
411
Issue
1-2
Year of publication
2001
Pages
67 - 70
Database
ISI
SICI code
0014-2999(20010105)411:1-2<67:AACPIT>2.0.ZU;2-Q
Abstract
The action of antidepressants on cell proliferation (bromodeoxyuridine (Brd U) or [H-3]thymidine incorporation} was studied in the adult rat hippocampu s in vivo and in neural precursors (immature rat cerebellar granule cells) in vitro. In vivo, prolonged (21 days) but not acute (single) intraperitone al treatment with fluoxetine (5 mg/kg) resulted in a 3.4-fold increase of b romodeoxyuridine-positive cells in the subgranular zone of the dentate gyru s. In cell cultures, at 1 and 10 days in vitro, 48-h fluoxetine exposure (1 muM. which is comparable to therapeutic plasma concentrations) reduced thy midine incorporation when initiated at 1 day in vitro, but increased cell p roliferation when initiated at 10 days in vitro. Clomipramine and imipramin e produced similar action in vitro; desipramine was ineffective. (C) 2001 E lsevier Science B.V. All rights reserved.