U. Nocentini et al., Patterns of cognitive impairment in secondary progressive stable phase of multiple sclerosis: Correlations with MRI findings, EUR NEUROL, 45(1), 2001, pp. 11-18
Cognitive impairment is commonly described in multiple sclerosis (MS), but
conflicting results have been reported about its pattern by previous studie
s focused on heterogeneous patient groups. The aim of this study was to inv
estigate the cognitive skills of a homogeneous group of secondary progressi
ve MS patients, and to examine the relationship of this impairment to MRI p
arameters. Forty-four MS patients underwent a series of neuropsychological
tests devised to explore the main cognitive domains, and T1- and T2-weighte
d brain MRI. Results showed the presence of deficits of attention, memory,
planning abilities, problem-solving and conceptual reasoning (frontal funct
ions) in a subgroup of MS patients. Correlations between the performance in
some 'frontal' tests and the extent of frontal robe MRI lesional area were
present, but rather unspecific, the same performance being also correlated
with the nonfrontal lesional area. These findings suggest that in MS, over
all macroscopic and microscopic brain damage is more important than the cor
responding focal brain disease, even in determining deficits of selective c
ognitive domains. Copyright 2001 S. Karger AG, Basel.