N-hydroxysulfamides as analog of N-hydroxyurea: Synthesis and biological evaluation

Authors
Hajri, AH Dewynter, G Criton, M Dilda, P Montero, JL
Citation
Ah. Hajri et al., N-hydroxysulfamides as analog of N-hydroxyurea: Synthesis and biological evaluation, HETEROAT CH, 12(1), 2001, pp. 1-5
Citations number
25
Categorie Soggetti
Chemistry
Journal title
HETEROATOM CHEMISTRY
ISSN journal
10427163 → ACNP
Volume
12
Issue
1
Year of publication
2001
Pages
1 - 5
Database
ISI
SICI code
1042-7163(2001)12:1<1:NAAONS>2.0.ZU;2-G
Abstract
A series of sulfa-analog of hydroxyurea, derived from N-hydroxysulfamide H2 NSO2NHOH, were synthesized starting from chlorosulfonyl isocyanate (CSI) an d O-substituted hydroxylamines. Their antiproliferative, antiviral (in syne rgy with ddI), and antifungal activities have been evaluated. (C) 2001 John Wiley & Sons, Inc.