P. Contini et al., Soluble HLA class I/CD8 ligation triggers apoptosis in EBV-specific CD8(+)cytotoxic T lymphocytes by Fas/Fas-ligand interaction, HUMAN IMMUN, 61(12), 2000, pp. 1347-1351
In the present study, we report that allogenic soluble HLA class I(sHLA-I)
molecules isolated from serum induce apoptosis on EBV-specific CD8(+) Fas() cytotoxic T lymphocytes (CTL). CTL apoptosis is induced by thc binding of
sHLA-I molecules to CD8 and its extent depends on the time of incubation w
ith sHLA-I molecules. Apoptosis is triggered by the interaction of Fas(+) C
TL with soluble Fas-ligand, which is released following che binding of sHLA
-I antigens to CD8 molecules. These results suggest that sHLA-I molecules m
ay regulate immune responses by inducing apoptosis in virus-specific CTL. (
C) American Society for Histocompatibility and Immunogenetics, 2000. Publis
hed by Elsevier Science Inc.