Novel immunodeficiency data servers

The Internet contains scientific information in increasing amounts. It is p ossible to obtain the latest information, and Web services can easily be ma intained and updated. We have set up three Internet ser vices an immunodefi ciencies. Immunodeficiency-related mutation information is available in imm unodeficiency mutation databases (IDbases). Currently 14 registries are dis tributed, including information about Bloom syndrome (BLMbase), X-linked ag ammaglobulinemia (BTKbase), X-linked and autosomal recessive chronic granul omatous diseases (CYBBbase for X-linked CGD, CYBAbase for p22(phox) deficie ncy NCF1base for p47(phox) deficiency NCF2base for p67(phox) deficiency), C D3 gamma and CD3 epsilon deficiencies (CD3Gbase, CD3Ebase), X-linked hyper- IgM syndrome (CD40Lbase), T-B+ severe combined immunodeficiency (JAK3base), V(D)J recombination defects (RAG1base, RAG2base), X-linked lymphoprolifera tive syndrome (SH2D1Abase), and ZAP-70 deficiency (ZAP70base). Information on laboratories analysing the genetic defects is collected to IDdiagnostics registry Due to the rareness of immunodeficiencies there are very few labo ratories performing genetic diagnostics. Such laboratories are Listed in ID diagnostics and physicians can use the registry to find a suitable laborato ry for their diagnostic needs. Immunodeficiency Resource (IDR) is a compreh ensive integrated knowledge base for all the information on immunodeficienc ies, including clinical, biochemical, genetic, structural and computational data and analyses. Air three services are available at http: //www.uta.fi/ imt/bioinfo/.