NOVEL DITHIOCARBAMATE CARBAPENEMS WITH ANTI-MRSA ACTIVITY

Authors
OHTAKE N IMAMURA H KIYONAGA H JONA H OGAWA M OKADA S SHIMIZU A MORIYA M SATO H TOMINAGA Y YAMADA K NAKANO M USHIJIMA R NAKAGAWA S
Citation
N. Ohtake et al., NOVEL DITHIOCARBAMATE CARBAPENEMS WITH ANTI-MRSA ACTIVITY, Bioorganic & medicinal chemistry letters, 7(13), 1997, pp. 1617-1622
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
13
Year of publication
1997
Pages
1617 - 1622
Database
ISI
SICI code
0960-894X(1997)7:13<1617:NDCWAA>2.0.ZU;2-F
Abstract
A new series of carbapenems, in which disubstituted-aminothiocarbonylt hio moiety, directly attached to the C-2 position, were prepared and e valuated for their antibacterial potency. These analogs showed potent activity against high-level MRSA, Among them, 9e and 9i were found to exhibit good in vivo efficacy comparable to that of vancomycin, for mo use septicemia model with high-level MRSA. (C) 1997 Elsevier Science L td.