SYNTHESIS AND CHARACTERIZATION OF POLYASPARTIC ACID CARBOHYDRATE CONJUGATES - MULTIVALENT SIALYL LEWIS(X)

Authors
THOMA G ERNST B SCHWARZENBACH F DUTHALER RO
Citation
G. Thoma et al., SYNTHESIS AND CHARACTERIZATION OF POLYASPARTIC ACID CARBOHYDRATE CONJUGATES - MULTIVALENT SIALYL LEWIS(X), Bioorganic & medicinal chemistry letters, 7(13), 1997, pp. 1705-1708
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
13
Year of publication
1997
Pages
1705 - 1708
Database
ISI
SICI code
0960-894X(1997)7:13<1705:SACOPA>2.0.ZU;2-W
Abstract
A protocol for the functionalization of polyaspartimide (PAI) with car bohydrates containing an amino funtion at the reducing end to give bio degradable neoglycoconjugates such as 4 is presented. Scope and limita tion of the strategy with respect to the preparation of multivalent si alyl Lewis(x) 5 are discussed. (C) 1997 Elsevier Science Ltd.