Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp enterica serovar Choleraesuis but mice lacking IL-2 are resistant

Authors
Nishimura, H Tagaya, M Tsunobuchi, H Suzuki, H Nakashima, I Yoshikai, Y
Citation
H. Nishimura et al., Mice lacking interleukin-2 (IL-2)/IL-15 receptor beta chain are susceptible to infection with avirulent Salmonella enterica subsp enterica serovar Choleraesuis but mice lacking IL-2 are resistant, INFEC IMMUN, 69(2), 2001, pp. 1226-1229
Citations number
11
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
2
Year of publication
2001
Pages
1226 - 1229
Database
ISI
SICI code
0019-9567(200102)69:2<1226:MLI(RB>2.0.ZU;2-Y
Abstract
Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susce ptible to infection with avirulent Salmonella enterica subsp. enterica sero var Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer c ell response was not evident for both types of deficient mice. A Th1 respon se was detected in IL-2(-/-) but not in IL-2/IL-15R beta (-/-) mice infecte d with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.