Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin

Authors
Erwin, JL DaSilva, LM Bavari, S Little, SF Friedlander, AM Chanh, TC
Citation
Jl. Erwin et al., Macrophage-derived cell lines do not express proinflammatory cytokines after exposure to Bacillus anthracis lethal toxin, INFEC IMMUN, 69(2), 2001, pp. 1175-1177
Citations number
7
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
2
Year of publication
2001
Pages
1175 - 1177
Database
ISI
SICI code
0019-9567(200102)69:2<1175:MCLDNE>2.0.ZU;2-Z
Abstract
We present evidence that Bacillus anthracis lethal toxin (LT) suppresses ra ther than induces proinflammatory cytokine production in macrophages. Suppr ession is observed with extremely low levels of LT and involves inhibition of transcription of cytokine messenger RNA. Thus, LT may contribute to anth rax pathogenesis by suppressing the inflammatory response.