Expression of tumor necrosis factor alpha and interleukin 1 beta in jejunaof volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms

Authors
Robinson, P Okhuysen, PC Chappell, CL Lewis, DE Shahab, I Janecki, A White, AC
Citation
P. Robinson et al., Expression of tumor necrosis factor alpha and interleukin 1 beta in jejunaof volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms, INFEC IMMUN, 69(2), 2001, pp. 1172-1174
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
2
Year of publication
2001
Pages
1172 - 1174
Database
ISI
SICI code
0019-9567(200102)69:2<1172:EOTNFA>2.0.ZU;2-T
Abstract
Jejunal biopsies from volunteers challenged with Cryptosporidium parvum wer e examined for tumor necrosis factor alpha (TNF-alpha) and interleukin (IL) -1 beta mRNA Postchallenge biopsies from 15 of 28 (54%) volunteers expresse d TNF-alpha; 14% expressed IL-1 beta. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-alpha and IL-1 beta are not key mediators of diarrhea in human cryptosporidiosis.