Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains

Authors
Gomez-Duarte, OG Pasetti, MF Santiago, A Sztein, MB Hoffman, SL Levine, MM
Citation
Og. Gomez-duarte et al., Expression, extracellular secretion, and immunogenicity of the Plasmodium falciparum sporozoite surface protein 2 in Salmonella vaccine strains, INFEC IMMUN, 69(2), 2001, pp. 1192-1198
Citations number
43
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
2
Year of publication
2001
Pages
1192 - 1198
Database
ISI
SICI code
0019-9567(200102)69:2<1192:EESAIO>2.0.ZU;2-B
Abstract
Deleting transmembrane alpha -helix motifs from Plasmodium falciparum sporo zoite surface protein (SSP-2) allowed its secretion from Salmonella enteric a serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Ty phimurium constructs secreting SSP-2 stimulated greater gamma interferon sp lenocyte responses than did nonsecreting constructs (P = 0.04).