T cells that react to the immunodominant Leishmania major LACK antigen prevent early dissemination of the parasite in susceptible BALB/c mice

Authors
Schilling, S Glaichenhaus, N
Citation
S. Schilling et N. Glaichenhaus, T cells that react to the immunodominant Leishmania major LACK antigen prevent early dissemination of the parasite in susceptible BALB/c mice, INFEC IMMUN, 69(2), 2001, pp. 1212-1214
Citations number
16
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
2
Year of publication
2001
Pages
1212 - 1214
Database
ISI
SICI code
0019-9567(200102)69:2<1212:TCTRTT>2.0.ZU;2-L
Abstract
Susceptibility of BALB/c mice to Leishmania major depends on the early prod uction of IL-4 by CD4(+) T cells which react to the parasite LACK antigen. Here, we show that LACK-specific cells are rapidly recruited to the site of infection and favor the early dissemination of L. major to the internal or gans.