RECOGNITION AND CLEAVAGE OF DNA BY A DISTAMYCIN-SALEN-CENTER-DOT-COPPER CONJUGATE

Authors
ROUTIER S BERNIER JL CATTEAU JP BAILLY C
Citation
S. Routier et al., RECOGNITION AND CLEAVAGE OF DNA BY A DISTAMYCIN-SALEN-CENTER-DOT-COPPER CONJUGATE, Bioorganic & medicinal chemistry letters, 7(13), 1997, pp. 1729-1732
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
13
Year of publication
1997
Pages
1729 - 1732
Database
ISI
SICI code
0960-894X(1997)7:13<1729:RACODB>2.0.ZU;2-W
Abstract
Linkage of a salen . Cu complex to a distamycin analogue leads to a hy brid molecule that binds selectively to AT-rich sequences in DNA. The cleavage of DNA in the presence of a reducing agent remains efficient but weakly selective. (C) 1997 Elsevier Science Ltd.