Migraine: dynamics of psychophysiologic pattern

85 patients with migraine without aura and 20 healthy individuals were exam ined between the attacks, before the attack, during and after it (1-2 days) . The examination included clinical-neurological analysis; psychological Sp ilberger's and Beck's tests, scale of alexithymia and complex algesic quest ionnaire; recording of the conditional negative wave; determination of noci ceptive flexor reflex; recording of trigeminal evoked potentials; spectral analysis of the heart's rhythms; polysomnographic study. Psychcphysiologic pattern characteristic for all the patients was established. Psychological and neurophysiological parameters changed synchronously in the periods befo re the attack, during and after it. Before the migraineous attack a specifi c pathologic integration increased and presented maximally (the activity of antinociceptive system weakens anxiety increased, tension of catecholamine rgic systems grew, hyperactivity in trigeninal sphere elevated, tolerance t o the pain decreased). A clear tendency to the reversibility of these chang es was observed after an attack. A dynamics revealed in the psychophysiolog ical pattern could serve as a predictor of a migraineous attack and open so me perspectives for prophylaxis of the algesic attack.